miR-33 INHIBITORS AND USES THEREOF TO DECREASE INFLAMMATION
摘要
<p>The inhibition of miRNA miR-33 is shown to promote the polarization of macrophages from an Ml to an M2 phenotype. MiR-33 inhibitors are therefore useful for treating inflammation in subjects. Endogenous microRNAs can be silenced using antagomirs. The miR-33 inhibitor is preferably an antagomir having a single - stranded nucleic acid sequence that is complementary to at least 12 contiguous nucleotides in miR-33 and therefore forms a duplex with miR-33 under physiological conditions.</p>
申请公布号
WO2012149557(A1)
申请公布日期
2012.11.01
申请号
WO2012US35855
申请日期
2012.04.30
申请人
NEW YORK UNIVERSITY;MOORE, KATHRYN, J.;RAYNER, KATEY, J.;SHEEDY, FREDERICK;FERNANDEZ-HERNANDO, CARLOS;SUAREZ, YAJAIRA