发明名称 |
HIGH-THROUGHPUT ASSAY FOR EVALUATING DIPEPTIDYL PEPTIDASE I ACTIVITY |
摘要 |
A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity. |
申请公布号 |
ZA201103730(B) |
申请公布日期 |
2012.10.31 |
申请号 |
ZA20110003730 |
申请日期 |
2011.05.20 |
申请人 |
JANNESSEN RESEARCH & DEVELOPMENT, LLC |
发明人 |
OLSON MATTHEW;TODD MATTHEW |
分类号 |
C07K;C12Q |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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