发明名称 |
DISRUPTORS OF EARLY/RECYCLING ENDOSOMES |
摘要 |
A delivery system for introducing a cargo molecule into cytosol of a living cell can include: a first membrane binding element linked to an endosomal compartment disrupting element through a first linker having one or more anionic moieties; and a second membrane binding element linked to an exogenous cargo molecule through a second linker having one or more anionic moieties, the second linker having a region that is selectively cleavable, wherein the first and second membrane binding elements both induce endocytosis into an early/recycling endosome and the endosomal compartment disrupting element destabilizes the early/recycling endosome such that the exogenous cargo molecule is released from the second membrane binding element and into the cytosol of the living cell. |
申请公布号 |
WO2010022051(A2) |
申请公布日期 |
2010.02.25 |
申请号 |
WO2009US54163 |
申请日期 |
2009.08.18 |
申请人 |
UNIVERSITY OF KANSAS;PETERSON, BLAKE, R. |
发明人 |
PETERSON, BLAKE, R. |
分类号 |
A61K47/18;A61K31/7105;A61K47/48;A61P35/00 |
主分类号 |
A61K47/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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