PROSTATE-SPECIFIC MEMBRANE ANTIGEN BINDING PROTEINS AND RELATED COMPOSITIONS AND METHODS
摘要
The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (PSMA) and are useful for the treatment of prostate cancer (e.g., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (BPH). In one embodiment, the multi-specific polypeptide therapeutics bind both PSMA-expressing cells and the T-cell receptor complex on T cells to induce target-dependent T-cell cytotoxicity, activation and proliferation.
申请公布号
WO2012145714(A2)
申请公布日期
2012.10.26
申请号
WO2012US34575
申请日期
2012.04.20
申请人
EMERGENT PRODUCT DEVELOPMENT SEATTLE, LLC;BLANKENSHIP, JOHN W.;SEWELL, ELAINE TODD;TAN, PHILIP
发明人
BLANKENSHIP, JOHN W.;SEWELL, ELAINE TODD;TAN, PHILIP