摘要 |
Disclosed are prodrugs of methyl hydrogen fumarate (monomethyl fumarate) according to formula (I), and methods for their preparation. Specific examples of compounds of formula (I) include: (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, bis-(2-methoxyethylamino)carbamoyl]methyl methyl (2E)but-2-ene-1,4-dioate, 1-{ 2-{ (2E)-3-(methoxycarbonyl)prop-2-enoyloxy]acetyl} (2S)pyrrolidine-2-carboxylic acid, (N-{ [tert-butyl)oxycarbonyl]methyl} -N-methylcarbamoyl)methyl methyl (2E)but-2ene1,4-dioate, and (1S)-1-[N,N-bis(2-methoxyethyl)carbamoyl]ethyl methyl (2E)but-2-ene-1,4-dioate. Compounds of formula (I) are useful for treating psoriasis, asthma, chronic obstructive pulmonary disease, cardiac insufficiency, left ventricular insufficiency, myocardial infarction, angina pectoris, Parkinson's disease, Alzheimer's disease, Huntington's disease, retinopathia pigmentosa, mitochondrial encephalomyopathy, transplantation rejection, multiple sclerosis,ischemia, reperfusion injury, AGE induced genome damage, inflammatory bowel disease, Crohn's disease, or ulcerative colitis. |