| 摘要 |
The present application relates to novel, anti-Target Epidermal Growth Factor Receptor (EGFR, GeneID1956) binder-drug conjugates (ADCs) of N,N-dialkyl auristatins, to effective metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for treating and/or preventing diseases, and to the use of said ADCs for producing pharmaceuticals for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases, such as cancers. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures. |
| 申请人 |
BAYER INTELLECTUAL PROPERTY GMBH;BAYER PHARMA AKTIENGESELLSCHAFT;LERCHEN, HANS-GEORG;EL SHEIKH, SHERIF;BEIER, RUDOLF;BRUDER, SANDRA;STELTE-LUDWIG, BEATRIX;JOERISEN, HANNAH;MAHLERT, CHRISTOPH;GREVEN, SIMONE;PETRUL, HEIKE;SCHUHMACHER, JOACHIM;LINDEN, LARS;WILLUDA, JOERG;KOPITZ, CHAROTTE, CHRISTINE;GOLFIER, SVEN;HEISLER, IRING;HARRENGA, AXEL;THIERAUCH, KARL-HEINZ;BORKOWSKI, SANDRA |
发明人 |
LERCHEN, HANS-GEORG;EL SHEIKH, SHERIF;BEIER, RUDOLF;BRUDER, SANDRA;STELTE-LUDWIG, BEATRIX;JOERISEN, HANNAH;MAHLERT, CHRISTOPH;GREVEN, SIMONE;PETRUL, HEIKE;SCHUHMACHER, JOACHIM;LINDEN, LARS;WILLUDA, JOERG;KOPITZ, CHAROTTE, CHRISTINE;GOLFIER, SVEN;HEISLER, IRING;HARRENGA, AXEL;THIERAUCH, KARL-HEINZ;BORKOWSKI, SANDRA |
