发明名称 |
Method of Inducing an Immune Response |
摘要 |
A method is provided for inducing or enhancing an immune response in a mammal to a target polypeptide expressed in a plurality of cells of the mammal, which method comprises administering to the mammal an inhibitory nucleic acid which targets a region of a ribonucleic acid (RNA) which encodes said polypeptide. Also provided is a pharmaceutical composition comprising an inhibitory nucleic acid which targets a region of an RNA which encodes a target polypeptide expressed in a plurality of cells of a mammal, such that translation of an aberrant form of the target polypeptide occurs in said cells, said truncated form of the target polypeptide comprising one or more T cell epitopes; together with a pharmaceutically acceptable carrier or diluent. |
申请公布号 |
US2012269850(A1) |
申请公布日期 |
2012.10.25 |
申请号 |
US201213530002 |
申请日期 |
2012.06.21 |
申请人 |
MCMILLAN NIGEL;LEGGATT GRAHAM;GU WENYI |
发明人 |
MCMILLAN NIGEL;LEGGATT GRAHAM;GU WENYI |
分类号 |
A61K39/12;A61K31/7088;A61K39/00;A61P31/00;A61P31/12;A61P37/02 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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