STREPTOMYCES COERULEORUBIDUS STRAIN - ANTIBIOTIC DAUNORUBICIN PRODUCER

摘要

FIELD: medicine. ^ SUBSTANCE: Streptomyces coeruleorubidus strain 1533 VKPM As-890 is produced by a multistage mutagenic exposure of methylnitrosoguanidine and gamma-rays 60Co on the Streptomyces coeruleorubidus 2679 stock strain that is followed by sampling mutants on mediums containing streptomycin and carminomycin as selective agents. Antibiotic activity of the daunorubicin complex collected by the end of fermentation is increased more than twice as compared with the reference - 2500 and 950 respectively. ^ EFFECT: higher yield of daunorubicin. ^ 2 tbl, 1 ex