发明名称 |
MONOMERIC TRIOXANE AMIDE SULFUR COMPOUNDS |
摘要 |
Anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in Plasmodium berghei-infected mice. Selected anilides derivatives administered orally as one single-digit dose combined with mefloquine hydrochloride were completely curative, i.e., all 5 of the mice in the particular treatment group had no detectable parasitemia on day 30 post infection, gained as much weight by day 30 post infection as the control mice (no infection), and behaved normally. |
申请公布号 |
WO2012142575(A2) |
申请公布日期 |
2012.10.18 |
申请号 |
WO2012US33774 |
申请日期 |
2012.04.16 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;POSNER, GARY H.;SLACK, RACHEL D. |
发明人 |
POSNER, GARY H.;SLACK, RACHEL D. |
分类号 |
C07D493/18;A61K31/537;A61P33/06;A61P35/00;C07D493/08 |
主分类号 |
C07D493/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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