MICROPOROUS ZIRCONIUM SILICATE FOR THE TREATMENT OF HYPERKALEMIA
摘要
The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. Also disclosed is a method for preparing high purity crystals of UZSi-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.
申请公布号
WO2012109590(A3)
申请公布日期
2012.10.18
申请号
WO2012US24727
申请日期
2012.02.10
申请人
ZS PHARMA, INC;KEYSER, DONALD, JEFFREY;GUILLEM, ALVARO, F.