发明名称 |
MODIFICATION OF CXCR4 USING ENGINEERED ZINC FINGER PROTEINS |
摘要 |
Disclosed herein are methods and compositions for modulating activity of CXCR4 genes, for example using zinc finger transcription factors (ZF-TFs) or zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZF-TFs or ZFNs, vectors comprising polynucleotides encoding ZF-TFs or ZFNs and cells comprising polynucleotides encoding ZF-TFs or ZFNs and/or cells comprising ZF-TF or ZFNs are also provided. |
申请公布号 |
EP2408921(A4) |
申请公布日期 |
2012.10.10 |
申请号 |
EP20100753815 |
申请日期 |
2010.03.18 |
申请人 |
SANGAMO BIOSCIENCES, INC. |
发明人 |
HOLMES, MICHAEL C.;MILLER, JEFFREY C.;WANG, JIANBIN |
分类号 |
C12N15/66 |
主分类号 |
C12N15/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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