NOVEL TUBULIN INHIBITORS AND METHODS OF USING THE SAME

摘要

Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof: R2-Y-Z-Q-A-R1 Formula (I) wherein R1, R2, Y, Z, Q, and A are as defined. These compounds are inhibitors of tubulin polymerization by binding at colchicines binding site and are useful in the treatment of tumors or mitotic diseases such as cancers, gout, and other conditions associated with abnormal cell proliferation.