METHODS AND COMPOSITIONS FOR UNSILENCING IMPRINTED GENES
摘要
The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.
申请公布号
WO2012064806(A3)
申请公布日期
2012.10.04
申请号
WO2011US59893
申请日期
2011.11.09
申请人
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;PHILPOT, BENJAMIN DAVID;ZYLKA, MARK JOHN;ROTH, BRYAN LEO;ALLEN, JOHN ARTHUR;HUANG, HSIEN-SUNG
发明人
PHILPOT, BENJAMIN DAVID;ZYLKA, MARK JOHN;ROTH, BRYAN LEO;ALLEN, JOHN ARTHUR;HUANG, HSIEN-SUNG