发明名称 |
AGENTS FOR PROMOTING TISSUE REGENERATION BY RECRUITING BONE MARROW MESENCHYMAL STEM CELLS AND/OR PLURIPOTENT STEM CELLS INTO BLOOD |
摘要 |
It was revealed that the intravenous administration of HMGB-1 and S100A8 promoted the healing of skin ulcer by recruiting bone marrow-derived cells to the site of skin ulcer. Furthermore, when HMGB-1 was intravenously administered to cerebral infarction model mice after creation of cerebral infarction, bone marrow-derived cells expressing nerve cell markers were detected in their brain. A marked cerebral infarct-reducing effect was observed in mice intravenously administered with HMGB-1 as compared to the control. The post-cerebral infarction survival rate was increased in the intravenous HMGB-1 administration group. The involvement of bone marrow pluripotent stem cells in the process of bone fracture healing was assessed using mice, and the result demonstrated that bone marrow-derived cells distant from the damaged site migrated to the bone fracture site to repair the damaged tissue.
|
申请公布号 |
US2012251510(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
US201013503329 |
申请日期 |
2010.10.28 |
申请人 |
TAMAI KATSUTO;KANEDA YASUFUMI;YAMAZAKI TAKEHIKO;CHINO TAKENAO;SAGA KOTARO;ENDO MAYUMI |
发明人 |
TAMAI KATSUTO;KANEDA YASUFUMI;YAMAZAKI TAKEHIKO;CHINO TAKENAO;SAGA KOTARO;ENDO MAYUMI |
分类号 |
A61K38/17;A61K31/7088;A61K35/12;A61P17/00;A61P19/00;A61P25/00;C07K14/47;C12N5/0775;C12N5/10;C12N15/85 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|