发明名称 |
DELIVERY OF LARGE MOLECULAR WEIGHT BIOLOGICALLY ACTIVE SUBSTANCES |
摘要 |
The invention relates generally to intradermal, transdermal, and/or transmembrane delivery of biologically active substances in the epidermis and/or through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular surface, tissue or membrane. The biologically active substances may have a molecular weight no less than about 5.8 kDa to about 2,500 kDa, such as Hyaluronic Acid (HA). The biologically active substances may be deposited in a dermal patch containing a red algae polysaccharide-based matrix, wherein the red algae polysaccharide is an extract of Chondrus crispus at 2% by weight of the dermal patch. The invention provides systems and methods for enhanced intradermal, transdermal, and/or transmembrane delivery of such biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods. |
申请公布号 |
WO2012130336(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
WO2011EP58293 |
申请日期 |
2011.05.20 |
申请人 |
PRINCIPIUM EUROPE S.R.L.;PHOTOKINETIX INC.;JANSON, JULIEN;KRAFT, EDWARD R.;KULP, GABRIELA;MALANCHIN, ROSELLA |
发明人 |
JANSON, JULIEN;KRAFT, EDWARD R.;KULP, GABRIELA;MALANCHIN, ROSELLA |
分类号 |
A61K41/00;A61K8/02;A61K8/97;A61K9/00;A61K9/70;A61K45/06;A61K47/02;A61N5/06 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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