摘要 |
The present invention relates to stabilization of teriparatide for oral administration by forming of water-soluble complexes with soluble polysaccharides, e.g. ß-glucan, chitosan, alginic acid, or their salts. Orally administered peptide medicaments such as teriparatide exhibit very low biological availability, which is mainly caused by rapid degradation in the digestive tract by proteolytic enzymes, as well as low efficiency of transport through the intestinal wall to the blood circulation. It is an advantage of the pharmaceutical composition according to the invention that teriparatide in the complex form is protected from being digested by proteases, the complex not preventing absorption of teriparatide from the gastrointestinal tract to the blood at the same time. |
申请人 |
ZENTIVA, K.S.;ANTOSOVA, ZUZANA;JUNKOVA PETRA;PETKOVA, GALINA;RICHTEROVA KLARA;REZANKA, PAVEL;MACKOVA, MARTINA;FLIEGER, MIROSLAV;KRAL, VLADIMIR |
发明人 |
ANTOSOVA, ZUZANA;JUNKOVA PETRA;PETKOVA, GALINA;RICHTEROVA KLARA;REZANKA, PAVEL;MACKOVA, MARTINA;FLIEGER, MIROSLAV;KRAL, VLADIMIR |