发明名称 |
PROCESS FOR PREPARATION OF DRONEDARONE BY MESYLATION |
摘要 |
<p>The invention relates to a novel process for preparation of N-[2-n-butyl-3-[4-[3-(di-n- butylamino)-propoxy]-benzoyl]-benzofuran÷5-yl]methanesulfonamide (I) and pharmaceutical acceptable salts thereof, where a salt of (5-amino-2-butyl-l- berizofuran-3-yl){4-[3-(di-n-butylamino)propoxy]phenyl}methanone of formula (II) - where A is a mono- or dibasic acid forming an acid addition salt with the compound of formula (II), n is 1 if A is dibasic acid and n is 1 or 2 if A is a monobasic acid - is reacted with a mesylating reagent in a heterogen reaction, if desired, in the presence of a phase transfer catalyst. The invention also relates to the novel salts of compound of formula (II), for the preparation thereof and their use in the preparation of dronedarone.</p> |
申请公布号 |
WO2012131408(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
WO2012HU00019 |
申请日期 |
2012.03.27 |
申请人 |
SANOFI;FRIESZ, ANTAL;HUSZAR, CSABA |
发明人 |
FRIESZ, ANTAL;HUSZAR, CSABA |
分类号 |
C07D307/81 |
主分类号 |
C07D307/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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