DEVICES AND METHODS FOR DETECTION AND QUANTIFICATION OF NITRIC OXIDE IN A BIOLOGICAL MATERIAL

摘要

Disclosed are methods and devices for detecting and quantifying nitric oxide (NO) in a biological material. Exemplary methods include the steps of providing a biological material, contacting the biological material to an electrochemical sensor, performing amperometric measurements using electrodes within the sensor, and detecting an electrical signal indicative of an amount of NO present in the biological material. An exemplary electrochemical sensor includes a substrate, an electrode set disposed on the substrate, and an ionomer coating on the electrode set, an absorbent pad over the electrode set and a gas permeable membrane sealing the pad and the electrode set. In certain embodiments, the sensor provides NO gas capture functionality that allows specific measurement and quantification of nitric oxide.