PROCESS FOR THE PREPARATION OF ILOPERIDONE USING A NOVEL INTERMEDIATE

摘要

The present invention provides a novel process for the preparation of iloperidone using a novel intermediate. Thus for example, reacting 4-(3- chloropropoxy)-3-methoxy benzaldehyde with methyl magnesium iodide in ether and the reaction mass was heated for 6 hours at reflux temperature, the mass was cooled to ambient temperature and poured into a mixture of ice, water and dilute hydrochloric acid to obtain l-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanol.