| 发明名称 |
Compositions and Methods for Regulating Cytochrome c-Mediated Apoptosis by tRNA |
| 摘要 |
The invention relates to the discovery that tRNA is a potent regulator of cell survival, tRNA regulates the interaction between cytochrome c and Apaf-1 and subsequently Apaf-1 oligomerization into an apoptosome which in turn recruits and oligomerizes the caspase cascade which ultimately leads to cell death. Accordingly, the present invention provides compositions and methods for regulating cell survival.
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| 申请公布号 |
US2012252718(A1) |
申请公布日期 |
2012.10.04 |
| 申请号 |
US201013500271 |
申请日期 |
2010.10.06 |
| 申请人 |
YANG XIAOLU;MEI YIDE;YONG JEONGSIK;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
YANG XIAOLU;MEI YIDE;YONG JEONGSIK |
| 分类号 |
A61K38/00;A61K31/7088;C12N5/02;C12N5/071 |
主分类号 |
A61K38/00 |
| 代理机构 |
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