| 摘要 |
The invention provides compounds of the formula I (see formula I) The compounds of the invention may be used for treatment of pain, for example, acute, visceral, neuropathic or chronic pain. The compounds may also be used for treatment of an anxiety state, stress, a stress-associated syndrome, depression, catalepsy, epilepsy, Alzheimer's disease, senile dementia, a general cognitive dysfunction, a learning disorder as a nootropic, a memory disorder as a nootropic, withdrawal symptoms, alcohol abuse, drug abuse, medicament abuse, alcohol dependency, drug dependency, medicament dependency, a sexual dysfunction, a cardiovascular disease, hypotension, hypertension, tinnitus, pruritus, migraine, impaired hearing, deficient intestinal motility, impaired food intake, anorexia, obesity, a locomotor disorder, diarrhoea, cachexia, or urinary incontinence and a muscle relaxant, anticonvulsive or anaesthetic for co-administration with treatment with an opioid analgesic or with an anaesthetic, for diuresis, antinatriuresis, or anxiolysis, for modulation of neurotransmitter secretion and treatment of a neurodegenerative disease associated therewith, treatment of withdrawal symptoms and reducing addiction potential of opioids. The compounds may also be used as a muscle relaxant, anticonvulsive, or anaesthetic; for co-administration with treatment with an opioid analgesic or with an anaesthetic; for diuresis, antinatriuresis or anxiolysis; for modulation of movement activity; for modulation of neurotransmitter secretion and treatment of a neurodegenerative disease association therewith; and for one or both of treatment of withdrawal symptoms and reducing addiction potential of opioids.
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