PHARMACEUTICAL FORMULATIONS OF LORATADINE FOR ENCAPSULATION AND COMBINATIONS THEREOF.

摘要

This invention relates to a loratadine formulation suitable for encapsulation into a soft gel capsule or suitable dosage unit with improved functionality providing enhanced in vitro dissolution and bioavailability of loratadine. The invention also provides a formulation with improved functionality as a highly concentrated solution within a given fill volume in order to manufacture as small a capsule as possible to facilitate consumer acceptance and acceptable manufacturing costs. The invention also relates to a formulation of optimal stability suitable for supporting a fill composition compatible with the soft gel capsule dosage unit.