PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES

摘要

Disclosed is a process for the preparation of a cyclopropyl-amide derivative compound of formula (II) where the substituents are as disclosed in the description. The process comprises reacting a compound of formula (XXIII) with source of bisulphite; in a polar organic solvent; to yield the corresponding bisulfite, the compound of formula (XXVII); and reacting the compound of formula (XXVII) with a compound of formula (XXIV); in the presence of a reducing agent; in the presence of an organic or inorganic base; in an organic solvent; to yield the corresponding compound of formula (II).