SACRIFICIAL ELECTRODE DESIGN AND DELIVERY SPECIES SUITABLE FOR PROLONGED IONTOPHORESIS APPLICATION PERIODS

摘要

Disclosed is a wearable iontophoresis device for the prolonged delivery of a positively charged pharmaceutical species from a salt formulation (such as donepezil hydrochloride) comprising: (a) a readily oxidisable metal-based sacrificial anode (such as silver) in the form of a generally planar layer having a connecting neck area that has a width that is generally 5% or more of the maximum electrode width dimension such that said sacrificial anode will remain connected for the desired operating life of the sacrificial anode; wherein the sacrificial anode is configured to have a minimum operating life of at least 6 hours under skin-safe conditions and is entirely consumed during the prolonged operation of the sacrificial anode; and (b) a drug delivery gel pad in electrical contact with said anode for accommodating a gel containing a positively charged pharmaceutical species in salt form formulated for transdermal delivery.