摘要 |
A method for utilizing a magnetically controlled pump implanted into a patient's brain or other organ for treatment of a solid tumoral mass. The pump delivers a plurality of medicating agents, including viral and non-viral vectors for gene therapy, and cell therapy, at a controlled rate, corresponding to the specific needs of the patient. The pump comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, the therapeutic agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. In cases where a tumor resection is not performed, or does not permit use of the MBP device, a catheter will be implanted in or adjacent to the tumoral region. Fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller. |
申请人 |
SHACHAR, YEHOSHUA;CHEN, THOMAS;WU, WINSTON;JORDAN, BRETT;CHAN, HERWIN;ZIMMERMAN, KYLE;LUBOFF, PALADIN;PHARMACO-KINESIS CORPORATION |
发明人 |
SHACHAR, YEHOSHUA;CHEN, THOMAS;WU, WINSTON;JORDAN, BRETT;CHAN, HERWIN;ZIMMERMAN, KYLE;LUBOFF, PALADIN |