| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies. <P>SOLUTION: This invention relates to a compound of formula (I) (wherein A is a 5-membered aromatic heterocycle or the like incorporating 1 to 4 heteroatoms N, O, or S; Q is H, alkyl, a carbocycle, or a heterocycle; X<SB POS="POST">1</SB>and X<SB POS="POST">2</SB>are each independently O or S; Y is a bond, (CR<SB POS="POST">7</SB>R<SB POS="POST">7</SB>)<SB POS="POST">n</SB>, O or S; n is 1 or 2; R<SB POS="POST">1</SB>is H; or R<SB POS="POST">1</SB>and R<SB POS="POST">2</SB>together form a 5-8 membered heterocycle; R<SB POS="POST">2</SB>is alkyl, a carbocycle or the like; R<SB POS="POST">3</SB>is H or alkyl; or R<SB POS="POST">3</SB>and R<SB POS="POST">4</SB>together form a 3-6 heterocycle; R<SB POS="POST">3</SB>' is H; or R<SB POS="POST">3</SB>and R<SB POS="POST">3</SB>' together form a 3-6 carbocycle; R<SB POS="POST">4</SB>and R<SB POS="POST">4</SB>' are independently H, hydroxyl or the like; R<SB POS="POST">5</SB>is H or alkyl; R<SB POS="POST">6</SB>, and R<SB POS="POST">6</SB>' are each independently H, alkyl or the like; R<SB POS="POST">7</SB>is H, cyano or the like; and R<SB POS="POST">8</SB>is H, alkyl or the like). The invention further relates to salts and solvates thereof. <P>COPYRIGHT: (C)2012,JPO&INPIT |
