发明名称 |
METHODS OF TREATING CANCER AND OTHER DISEASES |
摘要 |
Disclosed are a method of treating cancer in a cell, a method of enhancing the chemotherapeutic treatment of a cancer treatment agent, a method of reducing resistance of a cancer cell to a chemotherapeutic agent, a method of reducing the amount or activity of an ABC-family mRNA and/or protein, a method of reducing the amount or activity of the ABCB1 mRNA and/or protein or the ABCC1 mRNA and/or protein in an animal cell undergoing cancer treatment, a method of reducing the amount or activity of glutathione and/or Bcl2 in the cancer cell, a method of treating other multidrug resistant diseases, and a method of treating a multidrug resistant cell such as a bacterial multidrug resistant Staphylococcus aureus (MRSA), tuberculosis, fungal infection, or MDR malaria, by administering a compound of the Formula (I): a diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein R1-R4 are as described herein. Also disclosed are pharmaceutical compositions comprising a compound of formula (I), a diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. |
申请公布号 |
WO2012058269(A3) |
申请公布日期 |
2012.09.27 |
申请号 |
WO2011US57820 |
申请日期 |
2011.10.26 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;GOLDSBOROUGH, ANDREW S.;DULCEY, ANDRES;HANDLEY, MISTY;HALL, MATTHEW D.;BRIMACOMBE, KYLE;GRIFFITHS, GARY L.;GOTTESMAN, MICHAEL M. |
发明人 |
GOLDSBOROUGH, ANDREW S.;DULCEY, ANDRES;HANDLEY, MISTY;HALL, MATTHEW D.;BRIMACOMBE, KYLE;GRIFFITHS, GARY L.;GOTTESMAN, MICHAEL M. |
分类号 |
C07C321/04;A61K31/223;A61P35/00;C07C321/14 |
主分类号 |
C07C321/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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