发明名称 |
METHOD AND APPARATUS TO PERFORM HYDROGEN-DEUTERIUM EXCHANGE |
摘要 |
<p>Apparatus and methods to perform hydrogen/deuterium exchange using semipermeable membranes are described. The system has two channels separated by a semipermeable membrane. One channel comprises a flow carrying the analyte of interest, and the second channel comprises a solution comprising a deuterated solvent (e.g. deuterium oxide). The system does not require an external electric field gradient across the membrane to perform the hydrogen-deuterium exchange procedure. The present invention facilitates sample and reagent handling as well as simplifies manufacture of devices and/or instrumentation related to deuterium exchange. Further described is a chemical analyzation device for analyzing chemical compositions and/or compounds, and a method for analyzing chemical compounds and a computer program product for inducing a computer to perform steps in the method. Also described is a method for analyzing interactions between analytes and charged molecules, and calculating binding coefficients of the analytes with respect to the charged molecules.</p> |
申请公布号 |
EP2502257(A1) |
申请公布日期 |
2012.09.26 |
申请号 |
EP20100830294 |
申请日期 |
2010.11.16 |
申请人 |
BIOMOTIF AB |
发明人 |
LAVOLD, THORLEIF;ASTORGA WELLS, JUAN |
分类号 |
H01J49/04;C01B4/00;C01B5/02;C07K1/13;G01N30/06;G01N30/72;G01N33/68;G06F19/16 |
主分类号 |
H01J49/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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