发明名称 |
SMNDELTA7 DEGRON: NOVEL COMPOSITIONS AND METHODS OF USE |
摘要 |
<p>The present invention includes an isolated nucleic acid comprising a nucleic acid sequence encoding a SMN&Dgr;7 degron and the encoded polypeptide. The invention also includes inhibitors of SMN&Dgr;7 degron. The invention also includes compositions and methods for mitigating SMN deficiency by targeting inhibition of factors that mediate SMN&Dgr;7-degron dependent degradation of SMN&Dgr;7.</p> |
申请公布号 |
EP2501414(A2) |
申请公布日期 |
2012.09.26 |
申请号 |
EP20100832087 |
申请日期 |
2010.11.17 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
DREYFUSS, GIDEON;CHO, SUNGCHAN |
分类号 |
A61K48/00;C07K14/47 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|