USE OF FAS LIGAND TO SUPPRESS LYMPHOCYTE-MEDIATED IMMUNE RESPONSES

摘要

Soluble mouse and human Fas ligand polypeptides and methods for inhibitng T-lymphocyte-mediated immune responses, including those directed against autologous and/or heterologous tissues, e g., by a recipient mammal of a transplanted tissue, by providing the recipient mammal with Fas ligand. The Fas ligand may be provided to the recipient mammal by a variety of means,including by direct administration of the Fas ligand or by providing the gene encoding the Fas ligand to a subject such that Fas ligand is synthesized by the subject.