发明名称 |
PERFLUORO-T-BUTYL-CONTAINING COMPOUNDS FOR USE IN FLUORINE-19 NMR AND/OR MRI |
摘要 |
2064567 9101759 PCTABS00003 Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety is an excellent reporter group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for easy detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any chance of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance. Additionally, the PFTB moiety-containing compounds may be utilized to determine oxygen concentration in aqueous solutions present in animate and inanimate objects. |
申请公布号 |
CA2064567(A1) |
申请公布日期 |
1991.02.01 |
申请号 |
CA19902064567 |
申请日期 |
1990.07.19 |
申请人 |
JOHNS HOPKINS UNIVERSITY (THE);TOWSON STATE UNIVERSITY |
发明人 |
ROGERS, WALTER J., JR.;EVERETT, THOMAS S. |
分类号 |
A61K49/00;A61K49/06;(IPC1-7):A61K49/00 |
主分类号 |
A61K49/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|