发明名称 |
Nogo, Caspr, F3 NB-3 useful in the treatment of injury and disease to the central nervous system |
摘要 |
The application provides materials and methods for promoting myelination of neuronal axons in the CNS. These derive from the findings first that the molecules Nogo and Caspr interact with one another during establishment and maintenance of the axoglial junction, and secondly that the molecules F3 and NB-3 are capable of promoting oligodendrocyte maturation via interaction with Notch. The materials and methods provided may be used in the treatment of CNS damage, in particular the treatment of spinal cord injury, multiple sclerosis, epilepsy and stroke.
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申请公布号 |
US8273855(B2) |
申请公布日期 |
2012.09.25 |
申请号 |
US20070767595 |
申请日期 |
2007.06.25 |
申请人 |
XIAO ZHI-CHENG;JIANGSU NOVAVAC BIO-TEC CO., LTD. |
发明人 |
XIAO ZHI-CHENG |
分类号 |
C07K14/00;A61K38/00;A61K38/17;A61P9/00;A61P25/00;A61P25/08;G01N33/68 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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