发明名称 |
REVERSIBLY INACTIVATED ACIDIFIED PLASMIN |
摘要 |
The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. |
申请公布号 |
CA2389337(C) |
申请公布日期 |
2012.09.25 |
申请号 |
CA20002389337 |
申请日期 |
2000.11.13 |
申请人 |
BAYER CORPORATION |
发明人 |
ZIMMERMAN, THOMAS P.;NOVOKHATNY, VALERY;JIANG, SHAN;COLANDENE, JAMES |
分类号 |
C12N9/48;C12N9/99;A61B17/00;A61K9/19;A61K9/50;A61K38/00;A61K38/48;A61K47/02;A61K47/10;A61K47/12;A61K47/18;A61K47/22;A61K47/26;A61K47/36;A61K47/42;A61M25/00;A61P7/02;A61P9/10;C12N9/68;C12N9/72;C12N9/76;C12N9/96 |
主分类号 |
C12N9/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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