USE OF GLUCOSIDASE INHIBITOR, 1-BUTYL,2-HYDROXYMETHYL-PIPERIDINE-3ALPHA,4BETA,5-TRIOL, FOR THE PREPARATION OF A MEDICAMENT FOR THERAPY OF MUCOVISCIDOSIS

摘要

Glucosidase inhibitors are used to prepare medicaments for treating mucoviscidosis. - ACTIVITY - CNS-Gen.; Respiratory-Gen. - MECHANISM OF ACTION - Reactivator of cystic fibrosis transmembrane conductance regulator (CFTR) protein delF508 mutant. - N-butyl deoxynojirimycin had an EC50 of 123 mu M for restoring iodide efflux in CF15 human lung epithelial cells (which are homozygotic for the delF508 mutation) after stimulation with forskoline and genisteine.