发明名称 |
DIAZENIUMDIOLATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHOD OF TREATING CANCER |
摘要 |
Disclosed is a method of treating cancer in a patient comprising administering to the patient an effective amount of a diazeniumdiolated (N2O2-containing) compound or a pharmaceutically acceptable salt thereof, wherein the cancer cell has an elevated level of reactive oxygen species (ROS) and/or a decreased level of one or more of PRX1, PRX6, and OGG1, compared to a normal cell of the same tissue or tissue type. An example of a diazeniumdiolated compound is Formula (I), wherein X and Q are defined herein. Also disclosed are diazeniumdiolated compounds, pharmaceutical compositions, and methods of use including enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation. |
申请公布号 |
US2012238518(A1) |
申请公布日期 |
2012.09.20 |
申请号 |
US201013509431 |
申请日期 |
2010.11.12 |
申请人 |
MACIAG ANNA E.;KEEFER LARRY K.;SAAVEDRA JOSEPH E.;ANDERSON LUCY M.;CHAKRAPANI HARINATH;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT OF HEALTH AND HUMAN SERVICES |
发明人 |
MACIAG ANNA E.;KEEFER LARRY K.;SAAVEDRA JOSEPH E.;ANDERSON LUCY M.;CHAKRAPANI HARINATH |
分类号 |
A61K31/551;A61K31/495;A61K31/69;A61K31/704;A61P35/00;C07D243/08;C07D295/30 |
主分类号 |
A61K31/551 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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