| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compounds which modulate signal transduction associated with C5a-receptor interactions, can inhibit the pathogenic events, including chemotaxis, associated with anaphylatoxin activity contributing to the increase of such inflammatory and autoimmune conditions. <P>SOLUTION: This invention relates to 1-aryl-4-substituted isoquinoline analogues expressed by the following formula (I) (wherein R<SB POS="POST">1</SB>is hydrogen, alkyl, alkenyl or the like; R<SB POS="POST">2</SB>is -NR<SB POS="POST">4</SB>R<SB POS="POST">5</SB>, -CR<SB POS="POST">A</SB>R<SB POS="POST">B</SB>NR<SB POS="POST">4</SB>R<SB POS="POST">5</SB>or the like; R<SB POS="POST">3</SB>is halogen, hydroxy, amino, cyano, optionally substituted alkyl or the like; and Ar is phenyl, naphthyl, indolyl or the like). <P>COPYRIGHT: (C)2012,JPO&INPIT |
