The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
申请公布号
CA2829963(A1)
申请公布日期
2012.09.20
申请号
CA20122829963
申请日期
2012.03.12
申请人
JANSSEN BIOTECH, INC.
发明人
ALMAGRO, JUAN CARLOS;ANDERSON, GLENN MARK;CHI, ELLEN;MARTINEZ, CHRISTIAN;RAGHUNATHAN, GOPALAN;SWANSON, RONALD;TEPLYAKOV, ALEXEY;TSE, KAM-FAI;WU, SHENG-JIUM;ZHOU, HONG MIMI