发明名称 |
Poly(CPP-SA) Anhydride As A Reactive Barrier Matrix Against Percutaneous Absorption Of Toxic Chemicals |
摘要 |
The present invention relates to a protective agent suitable to protect the human skin against toxic materials, particularly against chemicals with nucleophilic sites. The active moiety is a polyanhydride derivative. The active transdermal retardant offers a barrier property and chemically and/or physically reacts with harmful chemicals to decrease percutaneous absorption. In the preferred embodiments, polyanhydride in its low molecular weight form reduced flux of nicotine and nitrofurazone significantly. Additionally, polyanhydride in its high molecular weight form prevented nicotine absorption and decreased nitrofurazone permeation dramatically. Moreover, the polyanhydride in its high molecular weight form reduced nitroglycerin flux to a lesser extent. |
申请公布号 |
US2012237471(A1) |
申请公布日期 |
2012.09.20 |
申请号 |
US201213422874 |
申请日期 |
2012.03.16 |
申请人 |
ERFAN MOHAMMAD;MOGHIMI HAMID REZA;HAERI AZADEH;JAFARZADEH KASHI TAHEREH SADAT;JAFARZADE FARHAD |
发明人 |
ERFAN MOHAMMAD;MOGHIMI HAMID REZA;HAERI AZADEH;JAFARZADEH KASHI TAHEREH SADAT;JAFARZADE FARHAD |
分类号 |
A61K31/775;A61P17/00;C08G63/66 |
主分类号 |
A61K31/775 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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