发明名称 |
PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF |
摘要 |
The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-1-(3-nitrophenyl)-propan-1-one (VII) according to the Scheme 2 below using the (2R,3R)—O,O′-dibenzoyltartaric chiral acid wherein said resolution is quantitative. The present invention also refers to some intermediate compounds of the new synthesis process of tapentadol. |
申请公布号 |
US2012232306(A1) |
申请公布日期 |
2012.09.13 |
申请号 |
US201013512989 |
申请日期 |
2010.11.30 |
申请人 |
MOTTA GIUSEPPE;VERGANI DOMENICO;BERTOLINI GIORGIO;EUTICALS S.P.A. |
发明人 |
MOTTA GIUSEPPE;VERGANI DOMENICO;BERTOLINI GIORGIO |
分类号 |
C07C209/78;C07C69/63;C07C209/68;C07C225/16;C07C233/43 |
主分类号 |
C07C209/78 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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