发明名称 |
PROCESS FOR PREPARATION OF CLOPIODOGREL BISULFATE FORM-1 |
摘要 |
An improved process for preparing crystalline form-1 of (S)-methyl 2-(2-chlorophenyl)-2-{6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl}acetate bisulfate (clopidogrel bisulfate) of formula I is provided The preparation comprises the straight conversion of an uncyclized material of (S)-methyl 2-[2-(thiophen-2-yl)ethylamino]-2-(2-chlorophenyl) acetate hydrochloride into clopidogrel bisulfate crystalline form-1 without any degradation of clopidogrel base |
申请公布号 |
US2012232274(A1) |
申请公布日期 |
2012.09.13 |
申请号 |
US201013508545 |
申请日期 |
2010.03.22 |
申请人 |
BURGER WOLFGANG;GUDAPARTHI OMPRAKASH;REDDY KONDA SRINIVASA;KUMAR SUNEEL K.;RAMANA VENKATA P.;PHARMAZELL GMBH |
发明人 |
BURGER WOLFGANG;GUDAPARTHI OMPRAKASH;REDDY KONDA SRINIVASA;KUMAR SUNEEL K.;RAMANA VENKATA P. |
分类号 |
C07D495/04 |
主分类号 |
C07D495/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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