| 摘要 |
Disclosed is a method of predicting disease outcome in a patient being treated for lung cancer. The method is based in part on the discovery that chromosomal copy number gains at Chr 19,34.7 Mb-35.6 Mb can be used for prognostic classification. In particular, the method comprises the steps of: a) providing a test sample from a patient; b) determining a copy number for the cyclin El gene in the test sample; c) comparing the copy number of the cyclin El gene in the test sample against a baseline copy number of two cyclin El genes, thereby determining the presence or absence of a copy number gain for the cyclin El gene in the test sample; and d) based on the presence or absence of a copy number gain for the cyclin El gene in the test sample, identifying the patient as having an increased risk of a poor disease outcome when compared to a baseline measure of disease outcome in patients having no copy number gain in the cyclin El gene, wherein the presence of a copy number gain in the cyclin El gene is predictive of poor disease outcome. |
