NOVEL FLAVI MYCIN COMPOUND, ANTIFUNGAL COMPOSITION INCLUDING SAME, AND METHOD FOR PRODUCING SAME

摘要

The present invention provides a flavi mycin compound represented by Formula 1 or Formula 2, an isomer thereof, a derivative thereof having peptide deformylase-inhibitory activity, a pharmaceutically acceptable salt thereof, or an antifungal composition including as an active ingredient a strain, a bacteria, or a culture thereof, which produce the flavi mycin compound that is represented by Formula 1 of Formula 2, and provides a composition for suppressing peptide deformylase activity. The present invention also provides a method for preventing or treating a microorganism-contracted disease using the antifungal composition, a method for sterilizing a microorganism or rendering same bacteriostatic, and a method for producing the compound or the derivative thereof using an Aspergillus flavips F543 strain. The compound or the strain of the present invention strongly inhibits the activity of the peptide deformylase, thereby having a strong antifungal property against a pathogenic microorganism or antibiotics-tolerant bacteria, and in particular, can be useful in treating contagious diseases which are caused by super bacteria by exhibiting antifungal activity to metacillin-resistant Staphyloscoccus aureus and quinolone-resistant Staphyloscoccus aureaus.