GAG BINDING PROTEIN

摘要

PROBLEM TO BE SOLVED: To provide a method and tool for inhibiting interaction of chemokines and their high affinity receptors on a leukocyte, and to provide a therapeutic treatment of inflammatory diseases.

SOLUTION: A method for introducing a GAG binding site into a property-defined protein comprises steps of identifying a region in a protein which is not essential for structure maintenance; and introducing a monobasic amino acid into the site and/or deleting in the site at least one bulky and/or acidic amino acid. The GAG binding site has a GAG binding affinity of Kd≤10 μM, preferably ≤1 μM, and more preferably ≤0.1 μM.

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