发明名称 |
PH-RESPONSIVE POLYMERS OF HISTIDINE-CONJUGATED POLY(ETHYLENE GLYCOL)/DEXTRAN BLOCK COPOLYMER |
摘要 |
PURPOSE: A dextran/methoxypolyethylene glycol block copolymer is provided to provide a pH-responsive controlled release drug support which can form membranes on a stent and can be used as a drug-carrying polymer having high curing effectiveness. CONSTITUTION: A dextran/methoxypolyethylene glycol block copolymer comprises a histidine-dextran-polyethylene glycol block copolymer prepared by covalent bonding histidine to a dextran/methoxypolyethylene glycol block copolymer, which is prepared by a block copolymerization of polyethylene glycol and dextran. The histidine-dextrane-polyethylene glycol block copolymer is prepared by converting the terminal dextran to a reducing end group, introducing an amine group, forming a dextran-polyethylene glycol block copolymer by block-copolymerizing polyethylene glycol to an amine group, and adding N-acetyl-L-histidine to covalently-bonded histidine.
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申请公布号 |
KR20120098204(A) |
申请公布日期 |
2012.09.05 |
申请号 |
KR20110018000 |
申请日期 |
2011.02.28 |
申请人 |
PUSAN NATIONAL UNIVERSITY HOSPITAL;PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION |
发明人 |
KANG, DAE HWAN;JEONG, YOUNG IL;CHUNG, CHUNG WOOK;CHOI, KYUNG HA |
分类号 |
C08G81/00;A61K31/337;A61K47/48;C08G83/00 |
主分类号 |
C08G81/00 |
代理机构 |
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