| 摘要 |
<p>An expression vector that comprises: (a) An OriP origin of replication from Epstein-Barr virus (EBV); (b) And SV40 origin of replication; (c) An insertion site for a gene of interest; (d) An EF-1alpha promoter operably linked to the insertion site; and optionally (e) A nucleic acid sequence encoding an antibody. The antibody can be an anti-TNFalpha antibody, an anti-IL-18 antibody or and anti-IL-12 antibody. The vector can be used to express the antibody in a mammalian host cell selected from COS or HEK-293-6E cells.</p> |
