MYH10 AS A NEW DIAGNOSTIC MARKER OF PATHOLOGIES RESULTING FROM RUNX1 INACTIVATION

摘要

The present invention relates to a method of diagnosing a pathology resulting from a runt related transcription factor 1 (RUNX1) inactivation in a subject, which comprises the step of i) determining the platelets' myosin non-muscle heavy chain 10 (MYH10) expression level in a biological sample from said subject, and wherein a detectable platelets' MYH10 expression level is indicative of a pathology resulting from a runt-related transcription factor 1 (RUNX1) inactivation, and to a kit for diagnosing a pathology resulting from a runt-related transcription factor 1 (RUNX1) inactivation in a subject comprising i) at least one antibody for determining the platelet MYH10 expression level in a biological sample from said subject, which can be used in a such a method.