USE OF A SPIROLIDE, ANALOGUES AND DERIVATIVES THEREOF FOR TREATING AND/OR PREVENTING PATHOLOGICAL CONDITIONS LINKED TO THE TAU AND BETA-AMYLOID PROTEINS

摘要

The present invention is in the field of biomedicine. Specifically, it relates to the use of a spirolide compound with the chemical structure:
for preparing a drug for the prevention and/or treatment of a pathology related to the increase in ²-amyloid protein and/or hyperphosphorylation of tau protein compared to control, where said spirolide compound is administered in the amount necessary to reach a concentration in the serum of equal to or less than 50 nM. The amount administered is preferably the amount necessary to reach a concentration in the serum of between 0.5 nM and 50 nM.