发明名称 |
Thermally-targeted delivery of medicaments including doxorubicin |
摘要 |
Elastin-like polypeptide (ELP) serves as a vector for thermally-targeted delivery of therapeutics, including cytotoxic chemotherapeutic drugs such as doxorubicin. Examples of an ELP-based delivery vehicle can comprise: (1) a cell penetrating peptide, such as a Tat peptide, (2) ELP, and (3) the lysosomally degradable glycylphenylalanylleucylglycine (GFLG) (SEQ ID NO: 3) spacer and a cysteine residue (SEQ ID NO: 4) conjugated to therapeutic such as doxorubicin, or an analog thereof. |
申请公布号 |
US8252740(B2) |
申请公布日期 |
2012.08.28 |
申请号 |
US20070162283 |
申请日期 |
2007.01.29 |
申请人 |
RAUCHER DRAZEN;BIDWELL, III GENE;PRIEBE WALDEMAR;FOKT IZABELA;THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER |
发明人 |
RAUCHER DRAZEN;BIDWELL, III GENE;PRIEBE WALDEMAR;FOKT IZABELA |
分类号 |
A61K38/02;C07K7/06;C07K14/00 |
主分类号 |
A61K38/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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