发明名称 |
MONO-LYSINE SALTS OF AZOLE COMPOUNDS |
摘要 |
Mono-lysine salts of triazole compounds having a secondary or tertiary hydroxy group are provided. More particularly, the new water-soluble triazole antifungal mono-lysine salt compounds, or solvates thereof, are provided having the general formula I: wherein A in formula I represents the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group. R and R1 in formula I can each be a hydrogen atom or an alkyl group having one to six carbon atoms. The novel water-soluble azole compounds are useful for the treatment of fungal infections and can be administered orally, topically and parenterally.
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申请公布号 |
CA2606185(C) |
申请公布日期 |
2012.08.28 |
申请号 |
CA20062606185 |
申请日期 |
2006.05.01 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
GAO, QI;CHEN, CHUNG-PIN H.;FAKES, MICHAEL G.;PENDRI, YADAGIRI R.;KIAU, SUSANNE;VAKKALAGADDA, BLISSE |
分类号 |
C07D405/14;A61K31/4196;A61K31/427;A61P31/04;C07C229/26;C07D417/06 |
主分类号 |
C07D405/14 |
代理机构 |
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