COMPOUNDS

摘要

A compound having: a bicyclic ring structure that comprises two fused six-membered carbon rings, wherein one of the rings is aromatic, and wherein one carbon in the bicyclic ring structure may optionally be replaced with a nitrogen, sulfur or oxygen, the bicyclic ring structure being substituted with an optionally substituted pendent aromatic ring, wherein the compound includes one or more acidic substituent group selected from sulfate, sulfonate, phosphate and carboxylate; and pharmaceutically acceptable salts, solvates and pro-drugs thereof. The compounds, pharmaceutically acceptable salts, solutes or pro-drugs thereof, may be used for the treatment of inappropriate angiogenesis, for example in the treatment of cancer, diabetic retinopathy, arthritis, psoriasis, atherosclerosis, macular degeneration, or hemangioma.